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Title:Melanotan, Afamelanotide, Scenesse, Melanotan 2 - information
Description:Read and learn everything about Melanotan, afamelanotide (SCENESSE) and melanotan 2; science, buy, administrate, side effects and more!
Keywords:melanotan, afamelanotide, Scenesse
Melanotan, Afamelanotide, Scenesse, Melanotan 2 - information
Side Effects
Scientific research
Melanotan (also called: MT, afamelanotide or
melanotan 1 or Scenesse) and Melanotan II (also called: MT II
or melanotan 2) are laboratory made analogs of the
which is produced by our body (to be exactly within the
pituitary gland). MT and MT 2 were developed at The Arizona
University together with Arizona's Cancer Center. Melanotan is a
straight, full length peptide. Melanotan 2 is a shortened,
circular version of the afamelanotide peptide. MT and MT II
cause sunless tanning of the human skin and MT II has libido
enhancement and spontaneous erections as extra effects. The
tanning effect by MT and MT 2 is more pronounced when the skin
has been exposed to UV light, but tanning of the skin will also
happen when the skin is not exposed to the sun/UV light.
Differences between melanotan and
melanotan 2
Melanotan's peptide structure is
almost the same as our endogenously produced melanocyte-stimulating hormone. MT is an agonist of the
melanocortin-1 receptor (located on melanocyte
cells) and when this receptor
is triggered it
eventually will cause tanning of the skin. MT 1 does not bind well
to other receptors.
Melanotan 2 has a shorter sequence of amino acids
and also has a slightly different form
then melanotan 1. Because of this subtle change, binding at receptors other than
the melanocortin-1 receptor is greater than that
of Melanotan 1. This receptor binding on other receptors then the
melanocortin-1 receptor results in some effects with MT-II usage
that the user will not notice in MT1 usage. MT2 also binds to
the melanocortin-3 and 4 receptors and this binding will cause
increases in sexual arousal.
Which of the two is better? In the opinion of the writer you should choose Melanotan 1 (afamelanotide / Scenesse)
because afamelanotide causes tanning with less side
effects then Melanotan 2. But if you like the spontaneous erections as a side effect and you want more bang for your buck then you should choose melanotan 2. Because the amino-acid sequence is shorter in the case of melanotan2, there are more MT2 peptide chains available compared to
MT1 on a mg for mg basis. This means that on a mg for mg basis
effectively you need much less in terms of milligram weight
of MT II to achieve similar tanning results compared to MT1. So in terms of
which MT has the most bang for it's buck most users will choose
So why is melanotan not officially on the market yet? It seems that
it is difficult to bring melanotan to the market because
it is said that authorities are not easily willing to give
approval for a medicine that will be mainly used for cosmetic
reasons. If they were to allow it, then the side-effects should
be acceptable compared to the cosmetic benefits. This is a moral
discussion which still is to be continued by the relevant
authorities. Therefore at present Clinuvel (the melanotan patent
holder) will firstly develop and bring melanotan for trial for
the treatment of clinical indications instead of cosmetic
tanning. Clinuvel will market melanotan as SCENESSE reg; (afamelanotide).
Clinuvel's SCENESSE reg; aims to provide photoprotection,
that is to help those who suffer from UV related skin disorders.
For more info about Clinuvel's afamelanotide's clinical
indications and plans to bring it to the market check out their
website at .
Dutch translation
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